Brisket & Cheddar Sandwich

Name: Brisket & Cheddar Sandwich
Prep time: 15 min
Cook time: 20 min
Total time: 35 min
Yield: 8
Cuisine: American
Ingredients: 2 lb leftover brisket, sliced; 2 cups beef stock; 8 brioche Buns; 1 tbsp unsalted butter; 1 1/2 tbsp flour; 1 cup heavy whipping cream; 4 oz white American cheese, diced; 4 oz cheddar, grated; 4 tbsp mayonnaise; 1 tbsp prepared horseradish

Feb 19, 2025 • Tom Jackson

If you’ve got leftover brisket from last night’s feast, this elevated Beef ‘n Cheddar sandwich is the perfect way to turn it into something spectacular. We’re swapping out the usual roast beef for smoky, tender brisket and pairing it with a rich, homemade cheese sauce that’s miles ahead of anything store-bought. To balance the flavors, we add a creamy horseradish mayo that brings just the right amount of tang and heat. Whether you're looking for a next-level lunch or a satisfying dinner, this upgraded classic delivers bold, comforting flavors in every bite.

Brisket & Cheddar Sandwich

Tom Jackson

Rated 5.0 stars by 1 users

Cuisine

American

Servings

8

Prep Time

15 minutes

Cook Time

20 minutes

Calories

552

Give leftover brisket a bold upgrade with this elevated Beef ‘n Cheddar. Smoky brisket, rich homemade cheese sauce, and tangy horseradish mayo come together for a sandwich that’s anything but ordinary.

Ingredients

For the Sandwich

2 lb leftover brisket, sliced
2 cups beef stock
8 brioche Buns

For the Cheese Sauce

1 tbsp unsalted butter
1 1/2 tbsp flour
1 cup heavy whipping cream
4 oz white American cheese, diced
4 oz cheddar, grated

For the Horseradish Mayo

4 tbsp mayonnaise
1 tbsp prepared horseradish

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Directions

For the Brisket

Slice the brisket thin and reheat in the beef stock.

For the Cheese Sauce

Melt the butter in a skillet and add the flour. Cook over medium low heat, stirring constantly to make the roux. Slowly add cream, stirring constantly. Whisk in the cheeses by the handful, until melted.

For the Horseradish Mayo

Whisk the mayonnaise and horseradish to combine.

To Build the Sandwich

Wrap your buns in wet paper towels. Steam in the microwave until softened.
Spread the horseradish mayo on the bottom bun. Pull slices of the brisket out of the warm beef stock and place on the bun. Spoon the cheese sauce over the brisket. Top with the top bun.

Recipe Note

Other Recipes You Might Enjoy:

Brisket Lettuce Tomato Sandwich

Sriracha Ranch Grilled Chicken Sandwich

Recipe Highlights and Insights:

All About Roux

Roux is the unsung hero of many classic dishes, silently working behind the scenes to transform a simple sauce or soup into something rich and velvety. This magical mixture of flour and fat isn't just a thickener; it’s a flavor enhancer, evolving from a pale paste to a nutty, golden brown concoction as it's cooked. Whether it's the foundation of a creamy béchamel, a rich cheese sauce, the backbone of a savory gumbo, or the secret to a smooth gravy, roux is one of those culinary techniques that, once mastered, elevates the entire dish. It’s a simple concept with a big payoff, making it a true kitchen staple.